Knigge U, Wollesen F, Dejgaard A, Larsen K, Christiansen P M
Horm Metab Res. 1983;15(2):89-91. doi: 10.1055/s-2007-1018637.
The effects of histamine (HA) on prolactin (PRL), ACTH, and cortisol secretion in human males were investigated. Specific H2 -receptor blockade caused an immediate and significant PRL release, while specific H2 -receptor stimulation (HA and mepyramine) was without effect on PRL secretion. HA significantly stimulated both ACTH and cortisol secretion, and this stimulation was probably mediated through H2 -receptors, H2 -receptor blockade caused a late, but significant ACTH release. This release was not accompanied by a release of cortisol, and might therefore be due to a spontaneous oscillation in ACTH secretion. The results support the theory that HA acts as a modulator of human ACTH secretion. A similar effect on PRL secretion as postulated by others could not be confirmed in this study.
研究了组胺（HA）对男性催乳素（PRL）、促肾上腺皮质激素（ACTH）和皮质醇分泌的影响。特异性H2受体阻断导致PRL立即且显著释放，而特异性H2受体刺激（HA和甲氧苄胺）对PRL分泌无影响。HA显著刺激ACTH和皮质醇分泌，这种刺激可能通过H2受体介导，H2受体阻断导致ACTH延迟但显著释放。这种释放未伴随皮质醇释放，因此可能是由于ACTH分泌的自发振荡。结果支持HA作为人类ACTH分泌调节剂的理论。本研究未证实其他人所假设的对PRL分泌的类似影响。
