豚鼠胎儿谷氨酸作为胎盘谷氨酰胺可能的前体物质。
Foetal glutamate as a possible precursor of placental glutamine in the guinea pig.
作者信息
Bloxam D L, Tyler C F, Young M
出版信息
Biochem J. 1981 Aug 15;198(2):397-401. doi: 10.1042/bj1980397.
The role of foetal glutamate as a source of placental glutamine was investigated in the near-term pregnant guinea-pig placenta perfused in situ through the umbilical vessels. With normal foetal amino acid concentrations there was a significant two-way exchange of glutamate between the placenta and foetal perfusate, but a net release of the amino acid from the placenta. Radioactively labelled glutamate carbon entering the placenta by this exchange was freely incorporated into intracellular glutamine, but only 1.5% of it was found in glutamine transported out into the foetal circulation. In the guinea pig, therefore, foetal glutamate does not appear to be a precursor of glutamine released from the placenta on the foetal side.
通过脐血管对妊娠晚期豚鼠胎盘进行原位灌注，研究了胎儿谷氨酸作为胎盘谷氨酰胺来源的作用。在胎儿氨基酸浓度正常的情况下，胎盘与胎儿灌注液之间存在显著的谷氨酸双向交换，但氨基酸从胎盘净释放。通过这种交换进入胎盘的放射性标记谷氨酸碳可自由掺入细胞内谷氨酰胺，但其中只有1.5%存在于转运到胎儿循环中的谷氨酰胺中。因此，在豚鼠中，胎儿谷氨酸似乎不是胎盘从胎儿侧释放的谷氨酰胺的前体。
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