妊娠豚鼠中胆绿素的还原以及胆红素和胆绿素的胎盘转运
Reduction of biliverdin and placental transfer of bilirubin and biliverdin in the pregnant guinea pig.
作者信息
McDonagh A F, Palma L A, Schmid R
出版信息
Biochem J. 1981 Jan 15;194(1):273-82. doi: 10.1042/bj1940273.
Abstract
Biliverdin was reduced to bilirubin in pregnant and foetal guinea pigs, and the 100000 g supernatant from homogenates of foetal liver, placenta and maternal liver showed high biliverdin reductase activity. The placental transport of unconjugated bilirubin and biliverdin was compared by injecting unlabelled and radiolabelled pigments into the foetal or maternal circulation and analysing blood collected from the opposite side of the placenta. Injected bilirubin crossed the placenta from foetus to mother and vice versa, but injected biliverdin did not appear to cross without prior reduction to bilirubin. The guinea-pig placenta is apparently more permeable to bilirubin than biliverdin. Reduction of biliverdin to bilirubin in the foetus may, therefore, be essential for efficient elimination of haem catabolites from the foetus in placental mammals.
摘要
在怀孕的和胎儿期的豚鼠中，胆绿素被还原为胆红素，并且来自胎儿肝脏、胎盘和母体肝脏匀浆的100000g上清液显示出高胆绿素还原酶活性。通过将未标记的和放射性标记的色素注入胎儿或母体循环，并分析从胎盘另一侧采集的血液，比较了未结合胆红素和胆绿素的胎盘转运情况。注入的胆红素从胎儿穿过胎盘进入母体，反之亦然，但注入的胆绿素在未预先还原为胆红素的情况下似乎不会穿过胎盘。豚鼠胎盘对胆红素的通透性显然比对胆绿素的通透性更高。因此，在胎儿中将胆绿素还原为胆红素对于胎盘哺乳动物中胎儿有效清除血红素分解代谢产物可能至关重要。
相似文献
1
Reduction of biliverdin and placental transfer of bilirubin and biliverdin in the pregnant guinea pig.妊娠豚鼠中胆绿素的还原以及胆红素和胆绿素的胎盘转运
Biochem J. 1981 Jan 15;194(1):273-82. doi: 10.1042/bj1940273.
2
Excretion of fetal biliverdin by the rat placenta-maternal liver tandem.
Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R749-56. doi: 10.1152/ajpregu.00487.2005. Epub 2005 Nov 3.
3
Bile pigment formation and excretion in the rabbit.家兔体内胆汁色素的形成与排泄
Comp Biochem Physiol A Comp Physiol. 1986;85(1):67-71. doi: 10.1016/0300-9629(86)90463-9.
4
Placental transport of sodium in the guinea-pig.豚鼠胎盘对钠的转运
J Physiol. 1977 Mar;265(3):691-703. doi: 10.1113/jphysiol.1977.sp011738.
5
Foetal glutamate as a possible precursor of placental glutamine in the guinea pig.豚鼠胎儿谷氨酸作为胎盘谷氨酰胺可能的前体物质。
Biochem J. 1981 Aug 15;198(2):397-401. doi: 10.1042/bj1980397.
6
The excretion pattern of biliverdin and bilirubin in bile of the small skate (Raja erinacea).小鳐（Raja erinacea）胆汁中胆绿素和胆红素的排泄模式。
J Comp Physiol B. 1987;157(1):61-6. doi: 10.1007/BF00702729.
7
Excretion of foetal bilirubin by the rat placenta-maternal liver tandem.大鼠胎盘-母体肝脏串联系统对胎儿胆红素的排泄
Placenta. 2003 May;24(5):462-72. doi: 10.1053/plac.2002.0959.
8
Kinetics of the formation of biliverdin during the photochemical oxidation of bilirubin monitored by column liquid chromatography.柱液相色谱法监测胆红素光化学氧化过程中胆绿素形成的动力学
J Chromatogr. 1986 Mar 7;375(2):245-53. doi: 10.1016/s0378-4347(00)83717-2.
9
Biliary bilirubin and biliverdin excretion in rabbits during fasting and feeding.禁食和喂食期间家兔胆汁中胆红素和胆绿素的排泄情况。
Cornell Vet. 1988 Jan;78(1):99-104.
10
Bile pigment composition and bilirubin esterification in the developing chick.
Pediatr Res. 1995 Sep;38(3):349-55. doi: 10.1203/00006450-199509000-00013.
引用本文的文献
1
Fetal and neonatal bilirubin metabolism.胎儿及新生儿胆红素代谢
Front Pediatr. 2023 Feb 7;10:1002408. doi: 10.3389/fped.2022.1002408. eCollection 2022.
2
Gilbert Syndrome and Genetic Findings in Children: A Tertiary-Center Experience from Turkey.儿童吉尔伯特综合征与基因研究结果：来自土耳其一家三级中心的经验
Turk Arch Pediatr. 2022 May;57(3):295-299. doi: 10.5152/TurkArchPediatr.2022.21291.
3
Long-Term Effects of Biliverdin Reductase a Deficiency in Mice: Impact on Redox Status and Metabolism.小鼠中胆红素还原酶a缺乏的长期影响：对氧化还原状态和代谢的影响
Antioxidants (Basel). 2021 Dec 20;10(12):2029. doi: 10.3390/antiox10122029.
4
The Role of Bilirubin and the Other "Yellow Players" in Neurodegenerative Diseases.胆红素及其他“黄色参与者”在神经退行性疾病中的作用
Antioxidants (Basel). 2020 Sep 22;9(9):900. doi: 10.3390/antiox9090900.
5
Experimental models assessing bilirubin neurotoxicity.评估胆红素神经毒性的实验模型。
Pediatr Res. 2020 Jan;87(1):17-25. doi: 10.1038/s41390-019-0570-x. Epub 2019 Sep 7.
6
Carbon monoxide prevents TNF-α-induced eNOS downregulation by inhibiting NF-κB-responsive miR-155-5p biogenesis.一氧化碳通过抑制 NF-κB 反应性 miR-155-5p 的生物发生来防止 TNF-α 诱导的 eNOS 下调。
Exp Mol Med. 2017 Nov 24;49(11):e403. doi: 10.1038/emm.2017.193.
7
Excretion of biliary compounds during intrauterine life.宫内生活期间胆汁化合物的排泄。
World J Gastroenterol. 2009 Feb 21;15(7):817-28. doi: 10.3748/wjg.15.817.
8
Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.有机阴离子转运多肽OATP - A、OATP - C和OATP - 8在胎儿胆红素经人胎盘 - 母体肝脏串联排泄途径中的作用。
Biochem J. 2003 May 1;371(Pt 3):897-905. doi: 10.1042/BJ20030034.
9
Electrophoretic characterization and genetics of human biliverdin reductase (BLVR; EC 1.3.1.24); assignment of BLVR to the p14 leads to cen region of human chromosome 7 in mouse-human somatic cell hybrids.人胆绿素还原酶（BLVR；EC 1.3.1.24）的电泳特性及遗传学研究；在小鼠-人类体细胞杂种中将BLVR定位于人类染色体7的p14至着丝粒区域。
Biochem Genet. 1983 Feb;21(1-2):123-33.
10
Some physical and immunological properties of ox kidney biliverdin reductase.牛肾胆绿素还原酶的一些物理和免疫学特性。
Biochem J. 1988 Oct 15;255(2):431-5. doi: 10.1042/bj2550431.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
REDUCTION OF BILIVERDIN-C-14 TO BILIRUBIN-C-14 IN VIVO.体内胆红素原-C-14还原为胆红素-C-14
Proc Soc Exp Biol Med. 1964 Dec;117:681-3. doi: 10.3181/00379727-117-29666.
3
BILIRUBIN METABOLISM IN THE FETUS.胎儿胆红素代谢
J Clin Invest. 1964 Jan;43(1):32-9. doi: 10.1172/JCI104891.
4
TRANSFER OF BILIRUBIN-C14 ACROSS MONKEY PLACENTA.胆红素-C14 通过猴胎盘的转运
Pediatrics. 1963 Sep;32:416-9.
5
[Research on bile from the unau, Choloepus hoffmanni Pet].[霍夫曼二趾树懒（Choloepus hoffmanni Pet）胆汁的研究]
Arch Int Physiol Biochim. 1963 Jan;71:117-8.
6
Bile pigment excretion in amphibia.两栖动物的胆色素排泄
Nature. 1961 Apr 29;190:452. doi: 10.1038/190452a0.
7
[Placental permeability to bilirubin].[胎盘对胆红素的通透性]
Geburtshilfe Frauenheilkd. 1958 Apr;18(4):360-2.
8
Preparation and properties of crystalline biliverdin IX alpha. Simple methods for preparing isomerically homogeneous biliverdin and [14C[biliverdin by using 2,3-dichloro-5,6-dicyanobenzoquinone.结晶型胆绿素IXα的制备及其性质。使用2,3-二氯-5,6-二氰基苯醌制备异构体均一的胆绿素和[14C]胆绿素的简单方法。
Biochem J. 1980 Aug 1;189(2):193-208. doi: 10.1042/bj1890193.
9
The early-appearing bilirubin in ducks.鸭体内早期出现的胆红素。
Can J Physiol Pharmacol. 1966 Sep;44(5):864-6. doi: 10.1139/y66-105.
10
Bile pigments in the chicken.
Res Vet Sci. 1967 Jul;8(3):280-2.
Zotero 插件