Mayer V, Rajcáni J, Mitrová E
Acta Virol. 1981 Nov;25(6):390-4.
Heterospecific autoantibodies to axonal neurofilaments of neurons in sera from five patients with Creutzfeldt-Jakob disease were detected with the use of cryostat section from normal human brain caudate nucleus. The antibody, visualized by the indirect immunofluorescence technique, was shown to bind complement. This allowed to achieve brighter staining either by the anticomplementary method alone or by a combination of both anti-C3 and anti-IgG conjugates
利用正常人脑尾状核的冰冻切片,检测了5例克雅氏病患者血清中针对神经元轴突神经丝的异种特异性自身抗体。通过间接免疫荧光技术观察到的这种抗体可结合补体。这使得仅通过抗补体方法或同时使用抗C3和抗IgG结合物的组合就能实现更亮的染色。