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克雅氏病中抗神经丝自身抗体:人尾状核切片的免疫荧光检测

Autoantibodies against neurofilaments in Creutzfeldt-Jakob disease: immunofluorescence in sections of human caudate nucleus.

作者信息

Mayer V, Rajcáni J, Mitrová E

出版信息

Acta Virol. 1981 Nov;25(6):390-4.

PMID:6120641
Abstract

Heterospecific autoantibodies to axonal neurofilaments of neurons in sera from five patients with Creutzfeldt-Jakob disease were detected with the use of cryostat section from normal human brain caudate nucleus. The antibody, visualized by the indirect immunofluorescence technique, was shown to bind complement. This allowed to achieve brighter staining either by the anticomplementary method alone or by a combination of both anti-C3 and anti-IgG conjugates

摘要

利用正常人脑尾状核的冰冻切片,检测了5例克雅氏病患者血清中针对神经元轴突神经丝的异种特异性自身抗体。通过间接免疫荧光技术观察到的这种抗体可结合补体。这使得仅通过抗补体方法或同时使用抗C3和抗IgG结合物的组合就能实现更亮的染色。

相似文献

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Autoantibodies against neurofilaments in Creutzfeldt-Jakob disease: immunofluorescence in sections of human caudate nucleus.克雅氏病中抗神经丝自身抗体:人尾状核切片的免疫荧光检测
Acta Virol. 1981 Nov;25(6):390-4.
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Antibodies to axonal neurofilaments in Creutzfeldt-Jakob disease and other organic dementias.
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Autoantibodies against axonal neurofilaments in patients with Kuru and Creutzfeldt-Jakob disease.库鲁病和克雅氏病患者中针对轴突神经丝的自身抗体。
Science. 1980 Oct 10;210(4466):190-3. doi: 10.1126/science.6997994.
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Characterization of antineurofilament autoantibodies in Creutzfeldt-Jakob disease.克雅氏病中抗神经丝自身抗体的特征分析。
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