Sotelo J, Gibbs C J, Gajdusek D C
Science. 1980 Oct 10;210(4466):190-3. doi: 10.1126/science.6997994.
The serums of some patients with subacute spongiform encephalopathies contain an autoantibody in higher titer against a normal fibrillar protein within the axon of mature central neurons in culture. The morphological features of this neurofilament, as demonstrated by immunofluorescence and immunoperoxidase staining, and the partial characterization of the antibody are described. The detection of this hetero-specific autoantibody is the first evidence of an immune reaction in the spongiform encephalopathies.
一些亚急性海绵状脑病患者的血清中含有一种自身抗体，其针对培养的成熟中枢神经元轴突内的正常纤维状蛋白的滴度较高。本文描述了通过免疫荧光和免疫过氧化物酶染色所显示的这种神经丝的形态学特征以及该抗体的部分特性。这种异特异性自身抗体的检测是海绵状脑病中存在免疫反应的首个证据。
