Helcl I, Lupolover R, Buch J P, Amrein R
Arzneimittelforschung. 1981;31(12a):2284-7.
In a double-blind parallel study performed in 40 hospitalized patients, suffering from mild to moderate insomnia, the efficacy and tolerance of 15 mg of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) administered p.o. were compared with those of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one (oxazepam) in the same dosage. The results show comparable values for the two drugs but with significantly better results for midazolam in the parameters: time taken to fall asleep and number of nocturnal awakenings.
在一项针对40名患有轻度至中度失眠的住院患者进行的双盲平行研究中，比较了口服15毫克8-氯-6-(2-氟苯基)-1-甲基-4H-咪唑并[1,5-a][1,4]苯二氮䓬（咪达唑仑，Ro 21-3981，多美康）与相同剂量的7-氯-1,3-二氢-3-羟基-5-苯基-2H-1,4-苯并二氮䓬-2-酮（奥沙西泮）的疗效和耐受性。结果显示两种药物的值相当，但在入睡时间和夜间觉醒次数参数方面，咪达唑仑的效果明显更好。
