Lupolover R, Ballmer U, Helcl J, Escher J, Pavletic B
Br J Clin Pharmacol. 1983;16 Suppl 1(Suppl 1):139S-143S. doi: 10.1111/j.1365-2125.1983.tb02285.x.
In a multicentre, double-blind, parallel study performed in 78 hospitalized patients who complained of mild, moderate or severe insomnia, the efficacy and safety of 15 mg midazolam were compared with those of 15 mg oxazepam, both orally administered. The results showed statistically significant better results in the onset of sleep in the patients treated with midazolam. Other sleep parameters, such as quality and duration of sleep as well as the condition of the patients on morning awakenings, were also improved in more patients treated with midazolam. Safety (clinical and biological) was very good in both groups of patients.
在一项针对78名抱怨有轻度、中度或重度失眠的住院患者进行的多中心、双盲、平行研究中，将口服15毫克咪达唑仑的疗效和安全性与15毫克奥沙西泮的疗效和安全性进行了比较。结果显示，接受咪达唑仑治疗的患者在入睡方面有统计学上显著更好的效果。其他睡眠参数，如睡眠质量和时长以及患者早晨醒来时的状况，在更多接受咪达唑仑治疗的患者中也得到了改善。两组患者的安全性（临床和生物学方面）都非常好。
