Kamp C W, Morgan W W
Eur J Pharmacol. 1982 Feb 5;77(4):343-6. doi: 10.1016/0014-2999(82)90141-8.
Sedative dosages of the benzodiazepine, diazepam (76 micro mol/kg, i.p.), reduce the light-evoked increase in retinal dopamine turnover, while intraocular applications of the water-soluble benzodiazepine, flurazepam (0.50 or 1.0 micro mol/eyeball), produce a dose-dependent suppression of light-enhanced dopamine synthesis. These results provide the first evidence that the benzodiazepines alter a physiologically important retinal response in vivo. They also suggest that some the visual effects produced by the benzodiazepines may have an intraretinal locus of action.
苯二氮䓬类药物地西泮的镇静剂量（76微摩尔/千克，腹腔注射）可降低光诱发的视网膜多巴胺周转率增加，而水溶性苯二氮䓬类药物氟西泮的眼内应用（0.50或1.0微摩尔/眼球）可产生剂量依赖性的光增强多巴胺合成抑制。这些结果首次证明苯二氮䓬类药物在体内改变了生理上重要的视网膜反应。它们还表明，苯二氮䓬类药物产生的一些视觉效应可能具有视网膜内作用位点。
