Maśliński S, Dzierzkowska J, Debski L, Kaleta Z
Acta Physiol Pol. 1977 Nov-Dec;28(6):515-20.
Influence of some inhibitors of histamine metabolism on the gastric secretion. Acta Physiol. Pol., 1977, 28 (6): 515-520. The influence of inhibitors of histamine metabolism on histamine (H) and Nalpha Nalpha-dimethylhistamine (NDMH) stimulated gastric secretion was studied in guinea-pigs and cats. Inhibitors of monoamine oxidase (MAO) and diamine oxidase (DAO): N-oxide diacetylaminopyridine (AAP) and N-oxide 2 aminopyridine (AP) increased HCI secretion in the gastric juice after H and NDMH. Inhibitors of N-methyl transferase: amodiaquine (A) and quinacrine (Q) increased HC1 secretion in the gastric juice after H but not after NDMH. The lack of action of A and Q on NDMH-stimulated gastric secretion suggests, that in guinea-pig and cat NDMH is not methylated additionally at the imidazole ring and therefore, it is a stronger gastric secretagogue than histamine itself.
某些组胺代谢抑制剂对胃液分泌的影响。《波兰生理学报》，1977年，28(6):515 - 520。在豚鼠和猫身上研究了组胺代谢抑制剂对组胺（H）和NαNα - 二甲基组胺（NDMH）刺激的胃液分泌的影响。单胺氧化酶（MAO）和二胺氧化酶（DAO）的抑制剂：N - 氧化物二乙酰氨基吡啶（AAP）和N - 氧化物2 - 氨基吡啶（AP）在H和NDMH作用后增加了胃液中盐酸的分泌。N - 甲基转移酶的抑制剂：阿莫地喹（A）和奎纳克林（Q）在H作用后增加了胃液中盐酸的分泌，但在NDMH作用后未增加。A和Q对NDMH刺激的胃液分泌无作用表明，在豚鼠和猫中，NDMH在咪唑环上不再额外甲基化，因此，它是比组胺本身更强的胃液分泌刺激剂。
