大鼠循环酮体、葡萄糖和胰岛素的空腹反应以及口服葡萄糖耐量试验随年龄的比较变化。

Comparative changes with age of the fasting response in circulating ketone bodies, glucose and insulin and oral glucose tolerance test in the rat.

Codina J, Vall M, Herrera E

Comp Biochem Physiol A Comp Physiol. 1982;71(2):231-6. doi: 10.1016/0300-9629(82)90393-0.

Abstract

Body weight loss in 48 hr fasted rats decreased with age. 2. Blood glucose and plasma RIA-insulin levels correlated negatively and positively respectively with body weight in fed rats. Fasting produced a greater fall in blood glucose and a smaller decrease in RIA-insulin in young than in old rats. 3. Blood ketone bodies correlated negatively with body weight after 48 hr fasting. 4. In oral glucose tolerance tests, blood glucose rose more in adult and old rats than in prepuberals when both fed and fasted. RIA-insulin levels rose more in prepuberals than in older rats when fed but not when fasted. 5. Changes in body composition and reduced insulin sensitivity with age are discussed.

摘要

禁食48小时的大鼠体重减轻随年龄增长而减少。2. 在喂食的大鼠中，血糖和血浆放射免疫分析胰岛素水平分别与体重呈负相关和正相关。与老年大鼠相比，禁食导致幼龄大鼠血糖下降幅度更大，放射免疫分析胰岛素下降幅度更小。3. 禁食48小时后，血酮体与体重呈负相关。4. 在口服葡萄糖耐量试验中，无论喂食还是禁食，成年和老年大鼠的血糖升高幅度均大于青春期前大鼠。喂食时，青春期前大鼠的放射免疫分析胰岛素水平升高幅度大于老年大鼠，但禁食时则不然。5. 讨论了随着年龄增长身体成分的变化和胰岛素敏感性的降低。