Junker U, Jaggi C, Bestetti G, Rossi G L
Acta Neuropathol. 1985;65(3-4):202-8. doi: 10.1007/BF00686999.
Basement membrane (BM) thickness of hypothalamic arcuate nucleus capillaries was measured in normotensive (WKY) and hypertensive (SHR) rats 4 and 8 months after streptozotocin or saline injection. Three groups were studied: controls (C), diabetics (D), and animals with impaired glucose tolerance (L). For comparison, BM thickness of cortical capillaries of an occipital and a frontal area was measured in three different layers starting from the pial surface. Independently from strain, hypothalamic capillary BM was thicker in older than in younger animals. At both 4 and 8 months, BM thickness was lowest in C, highest in D, and intermediate (between C and D) in L. Hypertension combined with diabetes did not further increase BM thickness. In both C and D no difference was found between the two cortical areas. The BM thickness of C increased from the superficial to the deep layer. In C hypertension induced BM thickening in the superficial frontal and the deep occipital layer. In the intermediate and the deep layer of the frontal area BM was thicker in WKY-D than in WKY-C. In every layer BM was thicker in SHR-D than in corresponding controls. Hypertension combined with diabetes enhanced BM thickening in the intermediate and the deep layer of the frontal and in the intermediate layer of the occipital area. Degenerative changes occurred in hypothalamic and cortical pericytes. These changes were more frequent in hypertensive than in normotensive animals. In conclusion, a microangiopathy characterized by BM thickening and pericytic degeneration occurs in the brain of diabetic animals. Its intensity and enhancement by a concomitant hypertension vary from hypothalamus to cortex.
在注射链脲佐菌素或生理盐水4个月和8个月后，测量正常血压（WKY）和高血压（SHR）大鼠下丘脑弓状核毛细血管的基底膜（BM）厚度。研究了三组：对照组（C）、糖尿病组（D）和糖耐量受损组（L）。为作比较，从软脑膜表面开始，在枕叶和额叶的三个不同层面测量皮质毛细血管的BM厚度。与品系无关，老年动物下丘脑毛细血管的BM比幼年动物的厚。在4个月和8个月时，BM厚度在C组最低，在D组最高，在L组居中（介于C组和D组之间）。高血压合并糖尿病并未进一步增加BM厚度。在C组和D组中，两个皮质区域之间均未发现差异。C组的BM厚度从浅层到深层增加。在C组中，高血压导致额叶浅层和枕叶深层的BM增厚。在额叶中间层和深层，WKY-D组的BM比WKY-C组厚。在每一层中，SHR-D组的BM比相应的对照组厚。高血压合并糖尿病增强了额叶中间层和深层以及枕叶中间层的BM增厚。下丘脑和皮质的周细胞发生了退行性变化。这些变化在高血压动物中比在正常血压动物中更频繁。总之，糖尿病动物脑内发生了以BM增厚和周细胞变性为特征的微血管病变。其严重程度以及伴随高血压的加重程度在下丘脑和皮质之间有所不同。
