Staniforth J N, Rees J E, Lai F K, Hersey J A
J Pharm Pharmacol. 1982 Mar;34(3):141-5. doi: 10.1111/j.2042-7158.1982.tb04210.x.
An ultracentrifuge technique, previously described by Staniforth et al (1981), has been used to study the adhesion profiles of several binary and ternary ordered powder mixes of pharmaceutical interest. The adhesion profile of an ordered mix provides information about the proportion of drug powder adhering with different forces of attraction to the carrier excipient particle surface. The excipient particle size is shown to affect adhesion between the components of a binary ordered mix-recrystallized lactose formed more stable ordered mixes with drug powder when the carrier particle size was increased. Changes in the adhesion profile of each binary system on adding three different fine-powder excipients to form a ternary ordered mix are also examined. The physical properties of carrier particles and the charge interactions of a third powder component with previously formed binary ordered mixes, are found to influence the physical stability of ternary ordered mixes.
一种先前由斯塔尼福思等人（1981年）描述的超速离心技术，已被用于研究几种具有药学意义的二元和三元有序粉末混合物的粘附特性。有序混合物的粘附特性提供了有关药物粉末以不同吸引力附着于载体辅料颗粒表面的比例的信息。结果表明，辅料颗粒大小会影响二元有序混合物各组分之间的粘附力——当载体颗粒尺寸增加时，重结晶乳糖与药物粉末形成更稳定的有序混合物。还研究了在每种二元体系中添加三种不同的细粉辅料以形成三元有序混合物时粘附特性的变化。发现载体颗粒的物理性质以及第三种粉末组分与先前形成的二元有序混合物之间的电荷相互作用会影响三元有序混合物的物理稳定性。
