对β受体阻滞剂心肌梗死后试验结果的信心。
Confidence in results of beta-blocker postinfarction trials.
作者信息
Baber N S, Lewis J A
出版信息
Br Med J (Clin Res Ed). 1982 Jun 12;284(6331):1749-50. doi: 10.1136/bmj.284.6331.1749.
Seventeen published trials of beta-blockers in myocardial infarction were scrutinised for the 95% confidence limits for the reported treatment effects. All the trials were prospective, randomised, and (except when treatment was given intravenously) placebo controlled. For analysis of pooled results the trials were divided arbitrarily according to whether treatment had been given "early" or "late" after the onset of pain. All trials were consistent with a treatment effect of just over 20%, but benefit was more apparent in trials using late intervention with beta-blockers. The pooled results of trials using early intervention showed a positive effect of 8%, whereas those using late intervention showed a 26% reduction in mortality and confidence limits of 17-35%. The results confirm that late intervention with beta-blockers after myocardial infarction reduces mortality but show that the effect of early intervention remains to be determined.
对17项已发表的关于β受体阻滞剂治疗心肌梗死的试验进行了审查，以确定所报告治疗效果的95%置信区间。所有试验均为前瞻性、随机且（除静脉给药治疗外）采用安慰剂对照。为分析汇总结果，根据疼痛发作后治疗是“早期”还是“晚期”给予，将试验任意分组。所有试验均显示治疗效果略高于20%，但在使用β受体阻滞剂进行晚期干预的试验中，益处更为明显。早期干预试验的汇总结果显示有8%的积极效果，而晚期干预试验的死亡率降低了26%，置信区间为17% - 35%。结果证实，心肌梗死后使用β受体阻滞剂进行晚期干预可降低死亡率，但表明早期干预的效果仍有待确定。
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