在英国、意大利和南斯拉夫的49家医院进行的普萘洛尔心肌梗死后多中心试验。
Multicentre post-infarction trial of propranolol in 49 hospitals in the United Kingdom, Italy, and Yugoslavia.
作者信息
Baber N S, Evans D W, Howitt G, Thomas M, Wilson T, Lewis J A, Dawes P M, Handler K, Tuson R
出版信息
Br Heart J. 1980 Jul;44(1):96-100. doi: 10.1136/hrt.44.1.96.
Abstract
A multicentre study of survivors of an anterior myocardial infarction is reported. The trial consisted of 720 patients and was a double-blind, placebo-controlled study with propranolol 40 mg three times a day. Trial entry was at two to 14 days (mean 8.5 days) and follow-up at one, three, and in most centres, six and nine months. The trial was designed to detect a 50 per cent reduction in mortality and this was not shown. The non-fatal reinfarction rate was similar in both groups. Subgroup analysis identified several prognostic risk factors for death, none of which interacted with treatment.
摘要
本文报道了一项关于前壁心肌梗死幸存者的多中心研究。该试验共有720名患者，是一项双盲、安慰剂对照研究，患者每日三次服用40毫克普萘洛尔。试验入选时间为发病后2至14天（平均8.5天），随访时间为1个月、3个月，多数中心还进行了6个月和9个月的随访。该试验旨在检测死亡率降低50%的效果，但未得到证实。两组的非致命性再梗死率相似。亚组分析确定了几个死亡的预后风险因素，其中没有一个与治疗有相互作用。
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Beta-adrenergic blockade in cardiac infarction.心肌梗死中的β-肾上腺素能阻滞剂
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Trial of propranolol in acute myocardial infarction.普萘洛尔治疗急性心肌梗死的试验。
Br Med J. 1968 May 18;2(5602):398-400. doi: 10.1136/bmj.2.5602.398.
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Absence of prophylactic effect of propranolol in myocardial infarction.普萘洛尔在心肌梗死中无预防作用。
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