与神经元损伤相关的微小终板电位

Miniature endplate potentials related to neuronal injury.

作者信息

Blight A R, Precht W

出版信息

Brain Res. 1982 Apr 22;238(1):233-8. doi: 10.1016/0006-8993(82)90789-2.

Abstract

Intracellular recordings were made in vivo from muscle fibers of anesthetized or spinalized frogs. Characteristic 'spontaneous' miniature endplate potentials were rarely recorded in intact muscles by comparison with muscles acutely denervated in the same animals. It is concluded that little or no spontaneous quantal release of transmitter occurs in vivo, in contrast with isolated preparations. The presence effectively 'silent' endplates was confirmed by evoking quantal release with hypertonic saline.

摘要

在麻醉或脊髓损伤的青蛙的肌肉纤维上进行了体内细胞内记录。与在同一只动物中急性去神经的肌肉相比，在完整肌肉中很少记录到特征性的“自发”微小终板电位。得出的结论是，与离体标本相比，体内很少或几乎没有递质的自发放量子释放。通过用高渗盐水诱发量子释放，证实了有效“沉默”终板的存在。