Minenko M L, Magazanik L G
Neirofiziologiia. 1986;18(3):346-54.
"Hump-like" distortions of evoked end-plate currents were observed with the help of extracellular focal recordings in sartorius and cutaneous frog muscle preparations at 20 degrees C. These distortions resembled spontaneous or unitary evoked responses by their amplitude and time course. Statistical analysis allowed rejecting the simplified assumption that these "humps" were the result of spontaneous nervous signals superimposed on the evoked ones. The asynchronous release of single quanta forming the multiquantal response seemed to be a more plausible explanation. A distinct correlation between the distribution of synaptic delay values of unitary responses (at low quantal content) and observed asynchronous responses (at high quantal content) was found. A polymodal pattern of distribution of synaptic delays was shown in both cases. It is concluded that the presence of asynchronous responses and discrete character of variations in synaptic delays are an intrinsic property of the transmitter release mechanism.
在20摄氏度下，通过细胞外局部记录，在缝匠肌和青蛙皮肤肌肉标本中观察到诱发终板电流的“驼峰状”畸变。这些畸变在幅度和时间进程上类似于自发或单一诱发反应。统计分析排除了一个简化假设，即这些“驼峰”是叠加在诱发信号上的自发神经信号的结果。形成多量子反应的单个量子的异步释放似乎是一个更合理的解释。发现单一反应（低量子含量时）的突触延迟值分布与观察到的异步反应（高量子含量时）之间存在明显相关性。在这两种情况下都显示出突触延迟分布的多峰模式。得出的结论是，异步反应的存在和突触延迟变化的离散特性是递质释放机制的固有属性。
