Sawada S, Takada S, Yamamoto C
Brain Res. 1982 Apr 22;238(1):282-5. doi: 10.1016/0006-8993(82)90798-3.
The actions of D- and D,L-homocysteate (DH and DLH) on CA3 neurons were studied in thin sections of the guinea pig hippocampus. DH and DLH administered to the stratum radiatum induced large depolarizations in CA3 neurons. The responses to DH and DLH were accompanied by increases in membrane conductance. The amplitudes of the responses increased and decreased, respectively, during tonic hyperpolarizing and depolarizing currents. In neurons injected with Cs+, these responses were reversed in polarity at membrane potentials of -13 to -19 mV. These results indicate that receptors for homocysteate in the hippocampus have different properties from those found in the spinal cord and are quite similar to glutamate receptors.
在豚鼠海马体薄片中研究了D-和D,L-同型半胱氨酸（DH和DLH）对CA3神经元的作用。将DH和DLH施用于辐射层可诱导CA3神经元产生大幅度去极化。对DH和DLH的反应伴随着膜电导增加。在强直超极化电流和去极化电流期间，反应幅度分别增大和减小。在注射Cs+的神经元中，这些反应在膜电位为-13至-19 mV时极性反转。这些结果表明，海马体中的同型半胱氨酸受体具有与脊髓中发现的受体不同的特性，并且与谷氨酸受体非常相似。
