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海马神经元对谷氨酸及其类似物的敏感性。

Sensitivity of hippocampal neurons to glutamic acid and its analogues.

作者信息

Yamamoto C, Sawada S

出版信息

Brain Res. 1982 Mar 11;235(2):358-62. doi: 10.1016/0006-8993(82)91014-9.

DOI:10.1016/0006-8993(82)91014-9
PMID:6145491
Abstract

In thin slices of the guinea-pig hippocampus, depolarizations induced by glutamate (Glu) and its analogues were studied by intracellular recording. It was found that Glu induced stereospecific responses, that L-Glu was more potent than homocysteate and N-methyl-D-aspartate. It is probable that the high-affinity uptake mechanism played a decisive role in termination of L-Glu excitation.

摘要

在豚鼠海马体的薄片中，通过细胞内记录研究了谷氨酸（Glu）及其类似物诱导的去极化。发现Glu诱导立体特异性反应，L-Glu比同型半胱氨酸和N-甲基-D-天冬氨酸更有效。高亲和力摄取机制可能在L-Glu兴奋的终止中起决定性作用。

相似文献

1
Sensitivity of hippocampal neurons to glutamic acid and its analogues.海马神经元对谷氨酸及其类似物的敏感性。
Brain Res. 1982 Mar 11;235(2):358-62. doi: 10.1016/0006-8993(82)91014-9.
2
Inhibitors of high-affinity uptake augment depolarizations of hippocampal neurons induced by glutamate, kainate and related compounds.高亲和力摄取抑制剂增强了由谷氨酸、海人酸及相关化合物诱导的海马神经元去极化。
Exp Brain Res. 1985;60(2):323-9. doi: 10.1007/BF00235927.
3
Membrane potential fluctuations associated with glutamate- and homocysteate-induced depolarizations in hippocampal neurons.与海马神经元中谷氨酸和高半胱氨酸诱导的去极化相关的膜电位波动。
Neurosci Lett. 1983 Oct 10;40(3):257-62. doi: 10.1016/0304-3940(83)90048-4.
4
Excitatory actions of homocysteic acid on hippocampal neurons.高半胱氨酸对海马神经元的兴奋作用。
Brain Res. 1982 Apr 22;238(1):282-5. doi: 10.1016/0006-8993(82)90798-3.
5
Some properties of ionic channels activated by excitatory amino acids in hippocampal neurons.海马神经元中由兴奋性氨基酸激活的离子通道的一些特性。
Exp Brain Res. 1985;57(2):313-20. doi: 10.1007/BF00236537.
6
Electrogenic uptake contributes a major component of the depolarizing action of L-glutamate in rat hippocampal slices.电生性摄取是L-谷氨酸对大鼠海马切片去极化作用的主要组成部分。
Br J Pharmacol. 1991 Feb;102(2):355-62. doi: 10.1111/j.1476-5381.1991.tb12178.x.
7
L-homocysteic acid but not L-glutamate is an endogenous N-methyl-D-aspartic acid receptor preferring agonist in rat neocortical neurons in vitro.
Neurosci Lett. 1987 Oct 16;81(1-2):188-92. doi: 10.1016/0304-3940(87)90363-6.
8
Conductance changes induced by DL-homocysteic acid and N-methyl-DL-aspartic acid in hippocampal neurons.DL-高半胱氨酸和N-甲基-DL-天冬氨酸对海马神经元电导的影响
Brain Res. 1982 Sep 9;247(1):149-53. doi: 10.1016/0006-8993(82)91040-x.
9
Desensitization to glutamate does not affect synaptic transmission in rat hippocampal slices.
Brain Res. 1983 Feb 14;261(1):167-71. doi: 10.1016/0006-8993(83)91299-4.
10
Suppressing action of 2-amino-4-phosphonobutyric acid on mossy fiber-induced excitation in the guinea pig hippocampus.
Exp Brain Res. 1983;51(1):128-34. doi: 10.1007/BF00236810.

引用本文的文献

1
Gamma-D-glutamylglycine and cis-2,3-piperidine dicarboxylate as antagonists of excitatory amino acids in the hippocampus.γ-D-谷氨酰甘氨酸和顺式-2,3-哌啶二羧酸作为海马体中兴奋性氨基酸的拮抗剂。
Exp Brain Res. 1984;55(2):351-8. doi: 10.1007/BF00237285.
2
Suppressing action of 2-amino-4-phosphonobutyric acid on mossy fiber-induced excitation in the guinea pig hippocampus.
Exp Brain Res. 1983;51(1):128-34. doi: 10.1007/BF00236810.
3
Action of excitatory amino acids and their antagonists on hippocampal neurons.兴奋性氨基酸及其拮抗剂对海马神经元的作用。
Cell Mol Neurobiol. 1985 Dec;5(4):389-405. doi: 10.1007/BF00755403.
4
Inhibitors of high-affinity uptake augment depolarizations of hippocampal neurons induced by glutamate, kainate and related compounds.高亲和力摄取抑制剂增强了由谷氨酸、海人酸及相关化合物诱导的海马神经元去极化。
Exp Brain Res. 1985;60(2):323-9. doi: 10.1007/BF00235927.
5
Repetitive firing of CA1 hippocampal pyramidal cells elicited by dendritic glutamate: slow prepotentials and burst-pause pattern.树突谷氨酸引发的海马CA1区锥体细胞重复放电：缓慢的预电位和爆发-暂停模式。
Exp Brain Res. 1985;60(1):10-8. doi: 10.1007/BF00237013.
6
Blocking action of pentobarbital on receptors for excitatory amino acids in the guinea pig hippocampus.戊巴比妥对豚鼠海马中兴奋性氨基酸受体的阻断作用。
Exp Brain Res. 1985;59(2):226-31. doi: 10.1007/BF00230901.
7
Some properties of ionic channels activated by excitatory amino acids in hippocampal neurons.海马神经元中由兴奋性氨基酸激活的离子通道的一些特性。
Exp Brain Res. 1985;57(2):313-20. doi: 10.1007/BF00236537.