吩噻嗪类抗精神病药物对致病性原生动物杜氏利什曼原虫的致死作用。

Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani.

作者信息

Pearson R D, Manian A A, Harcus J L, Hall D, Hewlett E L

出版信息

Science. 1982 Jul 23;217(4557):369-71. doi: 10.1126/science.6124040.

Abstract

Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.

摘要

吩噻嗪类药物因其抗精神病、抗焦虑和止吐作用而被广泛使用，现已发现它们对人类病原体杜氏利什曼原虫具有杀原虫作用。这些化合物对该生物体的细胞外阶段（由白蛉接种到人体内）和细胞内阶段（仅在已建立感染的人类巨噬细胞中发现）均具有致死性。