Neal R A, Allen S, McCoy N, Olliaro P, Croft S L
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
J Antimicrob Chemother. 1995 May;35(5):577-84. doi: 10.1093/jac/35.5.577.
The aminoglycoside, aminosidine exhibited ED50S of between 1 and 5 microM against the amastigotes of Leishmania major and Leishmania tropica in mouse peritoneal macrophages whereas other strains causing New World cutaneous leishmaniasis such as Leishmania braziliensis were more refractory. Aminosidine was also active against all but one of the Leishmania donovani strains tested and when combined with sodium stibogluconate, the drug showed marked potentiation against the amastigotes of L. donovani in vitro and an additive effect in experimentally infected BALB/c mice.
氨基糖苷类药物氨基胍定对小鼠腹腔巨噬细胞内的硕大利什曼原虫和热带利什曼原虫无鞭毛体的半数有效剂量（ED50）在1至5微摩尔之间，而其他引起新大陆皮肤利什曼病的菌株，如巴西利什曼原虫则更具耐药性。氨基胍定对除一种受试杜氏利什曼原虫菌株外的所有菌株均有活性，当与葡萄糖酸锑钠联合使用时，该药物在体外对杜氏利什曼原虫无鞭毛体显示出显著的增效作用，在实验感染的BALB/c小鼠中呈现相加效应。
