斑驳小鼠突变体中的铜代谢。铜疗法对花斑（Mobr）小鼠赖氨酰氧化酶活性的影响。
Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice.
作者信息
Royce P M, Camakaris J, Mann J R, Danks D M
出版信息
Biochem J. 1982 Feb 15;202(2):369-71. doi: 10.1042/bj2020369.
Abstract
Lysyl oxidase activity in extracts of skin from 1-day-old Mobr/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mobr/Y mice at 7 days of age with a single subcutaneous injection of 50 micrograms of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.
摘要
发现1日龄Mobr/Y小鼠皮肤提取物中的赖氨酰氧化酶活性为同年龄同窝+/Y小鼠相应提取物中酶活性的50%至60%。在7日龄时给Mobr/Y小鼠单次皮下注射50微克以Cu⁺形式保留在烷基聚醚/癸二酸溶液中的铜进行预处理后，其活性增加至后者的84%至150%。这表明以这种形式的铜能够绕过铜代谢中的障碍，并可输送至需要铜的过程。
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本文引用的文献
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Altered copper metabolism in cultured cells from human Menkes' syndrome and mottled mouse mutants.来自人类门克斯综合征和斑驳小鼠突变体的培养细胞中铜代谢的改变。
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Copper metabolism of cultured fibroblasts from the brindled mouse (gene symbol Mobr).斑驳小鼠（基因符号Mobr）培养成纤维细胞的铜代谢
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Reduced lysyl oxidase activity in skin fibroblasts from patients with Menkes' syndrome.门克斯综合征患者皮肤成纤维细胞中赖氨酰氧化酶活性降低。
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