Ivanova N A, Taros L Y, Grinbaum E B, Rumel N B, Kamforin L E, Luzyanina T Y
J Hyg Epidemiol Microbiol Immunol. 1976;20(2):186-94.
An analysis of morbidity of the population in the course of 3 influenza A/Hong-Kong epidemics showed a pronounced decrease in influenza affection of adult population in the last epidemic in 1971--1972. Comparative studies of the diagnostic value of CFR and HIT demonstrated identical sensitivity of CFR as a method of influenza diagnostics in both the epidemic and interepidemic periods. HIT was suitable for the detection of influenza only in the epidemic period. In the interepidemic period, the percentage of influenza infection diagnosed by means of HIT amounted to only 23--24 of all serologically confirmed cases of influenza. The highest percentage of virus isolation was observed when material from patients with serologically confirmed influenza was used. All strains of influenza A virus isolated in 1969 and 1970 were similar in their sensitivity to inhibitors of animal sera. Suring the last influenza epidemic, 2 of the 136 isolated strains were found to be resistant to gamma inhibitors and highly sensitive to the inhibitors showed their close relationship to gamma inhibitors. Antigenic analysis of the influenza A strains isolated during the 3 influenza epidemics revealed changes in the antigenic structure of the agents of the influenza epidemic in Leningrad in comparison with the standard strain A/Hong-Kong/I/68 (H3N2).
对3次甲型香港流感流行期间人群发病率的分析表明，1971 - 1972年最后一次流行中成年人群的流感感染率显著下降。对补体结合反应（CFR）和血凝抑制试验（HIT）诊断价值的比较研究表明，在流行期和非流行期，CFR作为流感诊断方法的敏感性相同。HIT仅适用于流行期流感的检测。在非流行期，通过HIT诊断出的流感感染病例在所有血清学确诊的流感病例中仅占23% - 24%。当使用血清学确诊流感患者的样本时，病毒分离率最高。1969年和1970年分离出的所有甲型流感病毒株对动物血清抑制剂的敏感性相似。在最后一次流感流行期间，136株分离株中有2株对γ抑制剂耐药，对显示出与γ抑制剂密切关系的抑制剂高度敏感。对3次流感流行期间分离出的甲型流感毒株进行的抗原分析显示，与标准毒株A/香港/1/68（H3N2）相比，列宁格勒流感流行病原体的抗原结构发生了变化。
