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1977/78年甲型H1N1流感病毒爆发:分离及血凝特性

Influenza A(H1N1) viruses of the 1977/78 outbreak: isolation and haemagglutination properties.

作者信息

Pyhälä R, Visakorpi R

出版信息

J Hyg (Lond). 1979 Feb;82(1):81-8. doi: 10.1017/s0022172400025493.

Abstract

During the H1N1 outbreak of 1977/8, the virus was isolated in embryonated eggs from 59 out of 76 patients (78%) with the serologically confirmed infection. A similar isolation frequency has been achieved during a period of six H3N2 outbreaks since 1972/3. The H1N1 strains were isolated less frequently from late specimens (collected 4--6 days from the onset of illness) and more often only in the second passage compared with the H3N2 viruses. The new H1N1 strains resembled those prevalent in the 1950s with respect to their ability to agglutinate erythrocytes of certain laboratory animals and to be eluted from these, and thus differed from the H3N2 viruses.

摘要

在1977/1978年H1N1流感爆发期间,从76例血清学确诊感染患者中的59例(78%)的鸡胚中分离出了病毒。自1972/1973年以来的六次H3N2流感爆发期间也获得了类似的分离频率。与H3N2病毒相比,H1N1毒株从后期标本(发病后4 - 6天采集)中分离的频率较低,且更多时候仅在第二代传代时才能分离到。新的H1N1毒株在凝集某些实验动物红细胞以及从这些红细胞上洗脱的能力方面与20世纪50年代流行的毒株相似,因此与H3N2病毒不同。

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