Lertratanangkoon K, Horning M G
Drug Metab Dispos. 1982 Jan-Feb;10(1):1-10.
Thirty-two metabolites of carbamazepine, in addition to the 10,11-epoxide, have been isolated from enzymatically hydrolyzed urine by HPLC and identified by gas-chromatographic and mass-spectrometric techniques. Eight were sulfur-containing methylthio, methylsulfinyl, or methylsulfonyl derivatives. Eighteen new metabolites, including five iminostilbene derivatives that have not been described earlier, were found. All of the metabolites were formed by processes involving epoxidation and a peroxidation, the structures of the metabolites support the hypothesis that multiple epoxides and a cyclic peroxide are involved in the in vivo metabolism of carbamazepine by the rat and man.
除10,11-环氧化物外，卡马西平的32种代谢物已通过高效液相色谱法从酶解尿液中分离出来，并通过气相色谱和质谱技术进行了鉴定。其中8种是含硫的甲硫基、甲亚磺酰基或甲磺酰基衍生物。发现了18种新的代谢物，包括5种之前未描述过的亚氨基茋衍生物。所有代谢物均通过涉及环氧化和过氧化的过程形成，代谢物的结构支持以下假设：多种环氧化物和一种环状过氧化物参与大鼠和人类体内卡马西平的代谢。
