Feurle G E, Spoleanschi P, Stauder M, Klempa I
Digestion. 1982;23(2):119-24. doi: 10.1159/000198700.
A dose-response study of the effect of 0.1-5.0 micrograms kg-1 h-1 somatostatin was performed on food-induced rise of pancreatic polypeptide and insulin in 4 dogs. There was a dose-dependent suppression of the release of pancreatic polypeptide and insulin with an ED50 of approximately 0.65 and 0.8 microgram kg-1 h-1, respectively, during the first 45-min period. In the second 45-min period, high doses of somatostatin failed to suppress insulin concentrations whereas, the serum concentrations of pancreatic polypeptide were reduced by a similar degree as in the first 45 min. The differing effects of somatostatin on food-stimulated serum concentrations of insulin and pancreatic polypeptide indicate that somatostatin does not represent a uniform suppressor of pancreatic hormones.
对4只狗进行了一项剂量反应研究，以探讨0.1 - 5.0微克/千克/小时生长抑素对食物诱导的胰多肽和胰岛素升高的影响。在最初的45分钟内，胰多肽和胰岛素的释放受到剂量依赖性抑制，其半数有效剂量（ED50）分别约为0.65和0.8微克/千克/小时。在第二个45分钟期间，高剂量的生长抑素未能抑制胰岛素浓度，而胰多肽的血清浓度降低程度与第一个45分钟相似。生长抑素对食物刺激的胰岛素和胰多肽血清浓度的不同影响表明，生长抑素并非胰腺激素的统一抑制剂。
