Ivarsson L, Darle N, Kewenter J G, Seeberg S, Norrby R
Am J Surg. 1982 Aug;144(2):257-61. doi: 10.1016/0002-9610(82)90521-9.
The efficacy of cefoxitin or doxycycline as antibiotic prophylaxis in colorectal surgery was compared in 102 elective operations. Both drugs were used perioperatively only. Cefoxitin was used in 55 cases and doxycycline in 47. Ten patients in the cefoxitin group and 4 in doxycycline group had wound infections. Three intraabdominal abscesses were seen, one after cefoxitin and two after doxycycline prophylaxis. All three were due to anastomotic leakage. Bacteriologic studies revealed no negative ecologic effects of prophylaxis. The short-term prophylaxis used did protect against serious infectious complications. The extended spectrum of cefoxitin provided no added benefit in prophylaxis. Patients with inflammatory bowel disease treated preoperatively with salicylazosulfapyridine run a greater risk of postoperative infection in spite of the prophylaxis.
在102例择期手术中比较了头孢西丁和多西环素作为结直肠手术抗生素预防用药的疗效。两种药物仅在围手术期使用。55例使用头孢西丁，47例使用多西环素。头孢西丁组有10例患者发生伤口感染，多西环素组有4例。观察到3例腹腔内脓肿，1例发生在使用头孢西丁预防后，2例发生在使用多西环素预防后。所有3例均因吻合口漏所致。细菌学研究显示预防用药无负面生态效应。所采用的短期预防用药确实可预防严重感染并发症。头孢西丁的广谱特性在预防方面未带来额外益处。术前用柳氮磺胺吡啶治疗的炎性肠病患者，尽管进行了预防，术后感染风险仍更高。
