肾移植中输血效应的可能作用机制。

Possible mechanism of action of transfusion effect in renal transplantation.

作者信息

MacLeod A M, Power D A, Mason R J, Stewart K N, Shewan W G, Edward N, Catto G R

出版信息

Lancet. 1982 Aug 28;2(8296):468-70. doi: 10.1016/s0140-6736(82)90496-2.

Abstract

The mechanism by which blood transfusions given before renal transplantation improves allograft survival was studied in 31 transplant recipients. The presence of non-cytotoxic, Fc receptor blocking antibodies to donor and leukaemic B lymphocytes in pre-transplant sera correlated with both improved graft survival (p less than 0.03 and less than 0.1, respectively) and the number of blood transfusions given (p less than 0.05 and less than 0.03, respectively). Moreover, 6 out of 10 previously untransfused prospective transplant recipients developed these potentially protective antibodies during a course of elective blood transfusions. These results indicate that such non-cytotoxic, Fc receptor blocking antibodies in pretransplant recipient sera (a) are associated with improved allograft survival, (b) correlate with the number of blood transfusions given, and (c) can develop in response to blood transfusion.

摘要

在31名肾移植受者中研究了肾移植前输血改善同种异体移植存活的机制。移植前血清中存在针对供体和白血病B淋巴细胞的非细胞毒性、Fc受体阻断抗体，这与移植存活的改善（分别为p<0.03和<0.1）以及输血次数（分别为p<0.05和<0.03）相关。此外，10名先前未输血的预期移植受者中有6名在择期输血过程中产生了这些潜在的保护性抗体。这些结果表明，移植前受者血清中的此类非细胞毒性、Fc受体阻断抗体：（a）与同种异体移植存活的改善相关；（b）与输血次数相关；（c）可因输血而产生。