脂质体包裹的第二抗体可改善用放射性标记的（第一）抗肿瘤抗体进行的肿瘤成像。

Liposomally entrapped second antibody improves tumour imaging with radiolabelled (first) antitumour antibody.

作者信息

Begent R H, Keep P A, Green A J, Searle F, Bagshawe K D, Jewkes R F, Jones B E, Barratt G M, Ryman B E

出版信息

Lancet. 1982 Oct 2;2(8301):739-42. doi: 10.1016/s0140-6736(82)90923-0.

Abstract

The usefulness of antibodies directed against tumour products for localisation and therapy of cancer is limited by the large proportion of administered antibody which remains non-specifically in the circulation and extravascular space. Liposomally entrapped second antibody (LESA) directed against the first (antitumour) antibody has been used to accelerate clearance of non-tumour-bound first antibody without affecting its clearance from the tumour. Intravenously administered LESA binds the first antibody and LESA is cleared by the reticuloendothelial system. LESA accelerated clearance of radiolabelled antibody directed against carcinoembryonic antigen (CEA) from the circulation in four of five patients with gastrointestinal cancer, enhancing gamma-camera imaging of the tumour in three of them. These results suggest that LESA can improve the sensitivity and specificity of tumour imaging with radiolabelled antitumour antibody. This strategy may also have the potential to improve the therapeutic ratio of some toxic agents linked to antitumour antibody.

摘要

针对肿瘤产物的抗体在癌症定位和治疗中的效用受到限制，因为大量注入的抗体仍非特异性地留存于循环系统和血管外间隙。针对第一种（抗肿瘤）抗体的脂质体包裹的第二抗体（LESA）已被用于加速未结合肿瘤的第一种抗体的清除，同时不影响其从肿瘤中的清除。静脉注射的LESA会结合第一种抗体，且LESA会被网状内皮系统清除。在五名胃肠道癌患者中，有四名患者静脉注射LESA后，其加速了循环中针对癌胚抗原（CEA）的放射性标记抗体的清除，其中三名患者的肿瘤γ相机成像得到增强。这些结果表明，LESA可提高放射性标记抗肿瘤抗体肿瘤成像的敏感性和特异性。该策略也可能有潜力提高与抗肿瘤抗体相连的某些毒性药物的治疗比率。