Dykes P W, Hine K R, Bradwell A R, Blackburn J C, Reeder T A, Drolc Z, Booth S N
Br Med J. 1980 Jan 26;280(6209):220-2. doi: 10.1136/bmj.280.6209.220.
Sheep IgG antibody to carcinoembryonic antigen (CEA) was radiolabelled with 131I and used to identify human gastrointestinal tumours by external subtraction imaging. 99Tc-pertechnetate and 99Tc-human serum albumin were used to identify tissue spaces. In 13 patients with tumours four out of five primary sites and eight out of 11 secondary sites were successfully shown. Two patients with benign disease had negative scans. Comparison with conventional methods of scanning showed good correlation. The success of this pilot study should encourage the search for more tumour-specific antigens and further study of the implications for treatment.
用131I对癌胚抗原（CEA）的绵羊IgG抗体进行放射性标记，并通过体外减影成像用于识别人类胃肠道肿瘤。用99Tc-高锝酸盐和99Tc-人血清白蛋白来识别组织间隙。在13例肿瘤患者中，5个原发部位中的4个和11个继发部位中的8个被成功显示。2例良性疾病患者扫描结果为阴性。与传统扫描方法的比较显示出良好的相关性。这项初步研究的成功应鼓励寻找更多肿瘤特异性抗原，并进一步研究其对治疗的意义。
