Lapierre Y D, Tremblay A, Gagnon A, Monpremier P, Berliss H, Oyewumi L K
J Clin Psychiatry. 1982 Sep;43(9):372-4.
The efficacy and safety of clobazam and diazepam were compared in 40 patients with generalized anxiety disorder in a 28 day non-placebo-controlled trial followed by a 3-day single-blind placebo washout. The two drugs were equally anxiolytic, and the anxiety symptoms of most patients were brought under control within 1 week. Both drugs were found to be nontoxic. Diazepam had slightly greater sedative properties than clobazam, which was the patients' preferred drug after 28 days of treatment. During placebo washout, anxiety returned to pretreatment levels. Abrupt withdrawal did not result in rebound phenomena.
在一项为期28天的非安慰剂对照试验中，对40例广泛性焦虑症患者比较了氯巴占和地西泮的疗效与安全性，随后进行了为期3天的单盲安慰剂洗脱期。两种药物的抗焦虑作用相当，大多数患者的焦虑症状在1周内得到控制。两种药物均无毒。地西泮的镇静作用略强于氯巴占，氯巴占是治疗28天后患者偏爱的药物。在安慰剂洗脱期，焦虑症状恢复到治疗前水平。突然停药未导致反跳现象。
