Jacobson A F, Goldstein B J, Dominguez R A, Steinbook R M
J Clin Psychiatry. 1983 Aug;44(8):296-300.
In a randomized, placebo-controlled, double-blind study, the efficacy and safety of clobazam and diazepam were compared in 114 anxious outpatients. During the 4-week double-blind phase of the study, the mean daily dose was 59 mg for clobazam and 25 mg for diazepam. Results indicate statistically significant efficacy, measured by both patient and physician rating scales, for both active drugs compared to placebo. The incidence of sedation was similar for the two active treatment groups; dizziness was more frequent in the diazepam group.
在一项随机、安慰剂对照、双盲研究中，对114名焦虑门诊患者比较了氯巴占和地西泮的疗效与安全性。在该研究为期4周的双盲阶段，氯巴占的平均日剂量为59毫克，地西泮为25毫克。结果表明，与安慰剂相比，两种活性药物在患者和医生评定量表上均显示出具有统计学意义的疗效。两个活性治疗组的镇静发生率相似；地西泮组头晕更为常见。
