van Hees P A, van Tongeren J H
J Clin Gastroenterol. 1982 Aug;4(4):333-6. doi: 10.1097/00004836-198208000-00008.
In patients with inflammatory bowel disease using a maintenance dose of sulfasalazine (SASP), compliance to therapy was studied by measuring serum sulfapyridine (SP) levels. Serum SP levels were determined in 51 patients both during hospitalization and at outpatient follow-up 1-6 months later. In 21 patients (41.2%) the serum SP level was considerably lower at outpatient follow-up than the serum level before discharge. In 21 (12%) of 175 outpatients taking a maintenance dose of SASP, SP in serum was not detectable at all at repeated determination during follow-up. These results indicate that a substantial number of patients on maintenance therapy with SASP do not take the prescribed dose. Drug trials in these patients should therefore incorporate methods of detecting defaulters.
在使用维持剂量柳氮磺胺吡啶（SASP）的炎症性肠病患者中，通过测量血清磺胺吡啶（SP）水平来研究治疗依从性。对51例患者在住院期间以及1 - 6个月后的门诊随访时测定血清SP水平。在21例患者（41.2%）中，门诊随访时的血清SP水平显著低于出院前的血清水平。在175例服用维持剂量SASP的门诊患者中，有21例（12%）在随访期间重复测定时血清中完全检测不到SP。这些结果表明，相当数量接受SASP维持治疗的患者未服用规定剂量。因此，针对这些患者的药物试验应纳入检测不依从者的方法。
