Persson B, Hedner T, Henning M
J Pharm Pharmacol. 1982 Jul;34(7):442-5. doi: 10.1111/j.2042-7158.1982.tb04753.x.
Following intravenous administration of ketanserin (0.3-10 mg kg-1) to conscious or anaesthetized normotensive and spontaneously hypertensive rats there were dose-dependent blood pressure reductions but no compensatory tachycardia. Intracerebroventricular administration of ketanserin (25-500 microgram) had inconsistent and largely insignificant cardiovascular effects. In a dose range where it produces hypotension ketanserin antagonized the pressor responses to adrenaline and noradrenaline as well as to 5-hydroxytryptamine in monoamine depleted and spinalized rats. It is suggested that the hypotensive action of ketanserin in the rat does not involve a central mechanism but a peripheral alpha-adrenolytic action is implicated.
给清醒或麻醉的正常血压和自发性高血压大鼠静脉注射酮色林（0.3 - 10毫克/千克）后，血压呈剂量依赖性降低，但无代偿性心动过速。脑室内注射酮色林（25 - 500微克）对心血管系统的影响不一致且大多不显著。在产生低血压的剂量范围内，酮色林可拮抗单胺耗竭和脊髓损伤大鼠对肾上腺素、去甲肾上腺素以及5 - 羟色胺的升压反应。提示酮色林在大鼠中的降压作用不涉及中枢机制，而是与外周α - 肾上腺素能阻断作用有关。
