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1
Generation of leukotriene C4 from a subclass of mast cells differentiated in vitro from mouse bone marrow.从小鼠骨髓体外分化的一类肥大细胞中生成白三烯C4。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4665-7. doi: 10.1073/pnas.79.15.4665.
2
IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells.IgE介导的白三烯C4、硫酸软骨素E蛋白聚糖、β-己糖胺酶和组胺从培养的骨髓来源的小鼠肥大细胞中的释放。
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3
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Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells.免疫激活的大鼠肠黏膜肥大细胞生成白三烯C4、白三烯B4和前列腺素D2 。
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Antigen-initiated release of platelet-activating factor (PAF-acether) from mouse bone marrow-derived mast cells sensitized with monoclonal IgE.抗原引发用单克隆IgE致敏的小鼠骨髓来源肥大细胞释放血小板活化因子（PAF-乙醚）。
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Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions.巨噬细胞炎性蛋白-1α作为肥大细胞介导的速发型超敏反应的共刺激信号。
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9
Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity.小鼠肥大细胞释放前列腺素D2：代谢物形成对其抗增殖活性的重要性。
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Two classes of mouse mast cells delineated by monoclonal antibodies.通过单克隆抗体划分出两类小鼠肥大细胞。
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本文引用的文献

1
The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock.过敏性休克期间组胺的释放及慢反应物质（SRS-A）的形成。
J Physiol. 1960 Jun;151(3):416-35. doi: 10.1113/jphysiol.1960.sp006449.
2
Structure of slow-reacting substance of anaphylaxis from guinea-pig lung.豚鼠肺过敏反应慢反应物质的结构
Nature. 1980 May 8;285(5760):104-6. doi: 10.1038/285104a0.
3
Long-term in vitro culture of murine mast cells. I. Description of a growth factor-dependent culture technique.小鼠肥大细胞的长期体外培养。I. 一种依赖生长因子的培养技术的描述。
J Immunol. 1981 Aug;127(2):788-94.
4
The persisting (P) cell: histamine content, regulation by a T cell-derived factor, origin from a bone marrow precursor, and relationship to mast cells.持久（P）细胞：组胺含量、受T细胞衍生因子的调节、起源于骨髓前体细胞以及与肥大细胞的关系。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):323-7. doi: 10.1073/pnas.78.1.323.
5
Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis.过敏反应迟缓反应物质中白三烯的放射免疫测定
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7692-6. doi: 10.1073/pnas.78.12.7692.
6
Culture from mouse bone marrow of a subclass of mast cells possessing a distinct chondroitin sulfate proteoglycan with glycosaminoglycans rich in N-acetylgalactosamine-4,6-disulfate.来自小鼠骨髓的一种肥大细胞亚类的培养物，该亚类具有一种独特的硫酸软骨素蛋白聚糖，其糖胺聚糖富含N-乙酰半乳糖胺-4,6-二硫酸盐。
J Biol Chem. 1982 Jun 25;257(12):7229-36.
7
Long-term in vitro culture of murine mast cells. II. Purification of a mast cell growth factor and its dissociation from TCGF.小鼠肥大细胞的长期体外培养。II. 肥大细胞生长因子的纯化及其与TCGF的解离
J Immunol. 1981 Aug;127(2):794-9.
8
Isolation and characterization of sulphated mucopolysaccharides from rat leukaemic (RBL-1) basophils.从大鼠白血病（RBL-1）嗜碱性粒细胞中分离和鉴定硫酸化粘多糖
Biochem J. 1980 Feb 1;185(2):367-72. doi: 10.1042/bj1850367.
9
Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity.鉴定白三烯A与半胱氨酸的C(6)-S缀合物作为一种天然存在的过敏反应慢反应物质（SRS-A）。11-顺式构型对生物活性的重要性。
Biochem Biophys Res Commun. 1980 Sep 16;96(1):271-7. doi: 10.1016/0006-291x(80)91210-3.
10
Growth of a pure population of mouse mast cells in vitro with conditioned medium derived from concanavalin A-stimulated splenocytes.利用伴刀豆球蛋白A刺激的脾细胞产生的条件培养基在体外培养纯系小鼠肥大细胞群体。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2559-61. doi: 10.1073/pnas.78.4.2559.

从小鼠骨髓体外分化的一类肥大细胞中生成白三烯C4。

Generation of leukotriene C4 from a subclass of mast cells differentiated in vitro from mouse bone marrow.

作者信息

Razin E, Mencia-Huerta J M, Lewis R A, Corey E J, Austen K F

出版信息

Proc Natl Acad Sci U S A. 1982 Aug;79(15):4665-7. doi: 10.1073/pnas.79.15.4665.

DOI:10.1073/pnas.79.15.4665
PMID:6126876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC346736/
Abstract

Bone marrow-derived mast cells, differentiated in vitro, demonstrate surface IgE, receptors and contain histamine in metachromatic granules, which are composed of chondroitin sulfate E proteoglycan rather than heparin proteoglycan. Activation of this subclass of mast cells with calcium ionophore A23187 resulted in generation of immunoreactive C-6-sulfidopeptide leukotriene in a dose- and time-dependent fashion. Isolation of immunoreactive C-6-sulfldopeptide leukotriene by reverse-phase high-performance liquid chromatography (RP-HPLC) revealed a retention time and a specific biologic activity identical to those of synthetic leukotriene C4 (LTC4). Neither radiolabeled nor immunoreactive conversion products of [3H]LTC4/LTC4 were recognized during RP-HPLC resolution of the supernatants. The failure of fresh bone marrow cultures to generate C-6-sulfidopeptide leukotriene in response to ionophore indicates that leukotriene generation is dependent upon cellular differentiation into a mast cell population. The amount of LTC4 generated during optimal ionophore stimulation, 90.9 +/- 7.5 ng per 10(6) cells, contrasts with the relatively low amounts of C-6-sulfidopeptide leukotriene generated by the conventional heparin-containing rat mast cells or mouse mastocytoma cells.

摘要

体外分化的骨髓源性肥大细胞表现出表面IgE受体，并且在异染颗粒中含有组胺，这些颗粒由硫酸软骨素E蛋白聚糖而非肝素蛋白聚糖组成。用钙离子载体A23187激活这类肥大细胞会以剂量和时间依赖的方式产生免疫反应性C-6-硫代肽白三烯。通过反相高效液相色谱（RP-HPLC）分离免疫反应性C-6-硫代肽白三烯，其保留时间和特定生物学活性与合成白三烯C4（LTC4）相同。在上清液的RP-HPLC分离过程中，未识别到[3H]LTC4/LTC4的放射性标记或免疫反应性转化产物。新鲜骨髓培养物对离子载体无反应而无法产生C-6-硫代肽白三烯，这表明白三烯的产生依赖于细胞分化为肥大细胞群体。在最佳离子载体刺激下产生的LTC4量为每10(6)个细胞90.9±7.5 ng，这与传统含肝素的大鼠肥大细胞或小鼠肥大细胞瘤细胞产生的相对少量的C-6-硫代肽白三烯形成对比。