Fuhrmann M, Zazgornik J, Duczak R, Panzer S, Hruby K, Korninger C, Kopsa H, Balcke P
Klin Wochenschr. 1982 Aug;60(15):811-2. doi: 10.1007/BF01721146.
Long-term administration of cimetidine, a histamine2 receptor antagonist, has been reported to normalize elevated parathyroid hormone (PTH) concentrations in patients with secondary [1] and primary hyperparathyroidism [2] and even to improve the clinical symptoms. We have compared the effect of cimetidine and pirenzepine on PTH and calcitonin (CT) plasma levels in a short-term trial on patients with secondary hyperparathyroidism. After cimetidine a significant effect on PTH was seen within 30 min lasting 30 min and after pirenzepine, within 60 min and lasting 60 min. The effect on CT was only significant after cimetidine.
据报道，组胺2受体拮抗剂西咪替丁的长期给药可使继发性甲状旁腺功能亢进患者[1]和原发性甲状旁腺功能亢进患者[2]升高的甲状旁腺激素（PTH）浓度恢复正常，甚至改善临床症状。我们在一项针对继发性甲状旁腺功能亢进患者的短期试验中比较了西咪替丁和哌仑西平对PTH和降钙素（CT）血浆水平的影响。服用西咪替丁后30分钟内对PTH有显著作用，持续30分钟，服用哌仑西平后60分钟内起作用，持续60分钟。仅在服用西咪替丁后对CT的作用才显著。
