Hayashi E, Maeda T, Shinozuka K
Eur J Pharmacol. 1982 Oct 15;84(1-2):99-102. doi: 10.1016/0014-2999(82)90162-5.
The sites of presynaptic actions of adenosine on electrically stimulated longitudinal muscle strip of guinea pig ileum were studied with a special dual organ bath. Local stimulation (0.1 Hz) of the anal part of the strip induced a twitch response in the stimulated part and in the non-stimulated oral part; both of these twitch responses were depressed by an application of adenosine to the anal, stimulated part of the strip. The present results suggested that electrical stimulation applied to the anal part of the strip travelled along the network of Auerbach's plexus in the oral direction, and adenosine might depress such conduction in cholinergic nerve fibers in addition to nerve terminals.
使用一种特殊的双器官浴槽，研究了腺苷对豚鼠回肠电刺激纵肌条的突触前作用位点。对肌条肛门部分进行局部刺激（0.1赫兹）会在刺激部分和未刺激的口腔部分诱发抽搐反应；将腺苷应用于肌条肛门的刺激部分会抑制这两种抽搐反应。目前的结果表明，施加于肌条肛门部分的电刺激沿奥尔巴赫神经丛网络向口腔方向传导，腺苷除了作用于神经末梢外，还可能抑制胆碱能神经纤维中的这种传导。
