吸入“海洛因”热解产物后的白质脑病。

Leucoencephalopathy after inhaling "heroin" pyrolysate.

作者信息

Wolters E C, van Wijngaarden G K, Stam F C, Rengelink H, Lousberg R J, Schipper M E, Verbeeten B

出版信息

Lancet. 1982 Dec 4;2(8310):1233-7. doi: 10.1016/s0140-6736(82)90101-5.

Abstract

47 patients with spongiform leucoencephalopathy but no other consistent abnormalities, except brown pigmentation of the alveolar macrophages in the lungs, are described. 11 patients have died. Epidemiological studies indicate at the cause of the illness the inhalatory use of poisoned heroin vapours (pyrolysate). The heroin is primarily sold on the black market in Amsterdam. The Netherlands. Over 170 suspect heroin samples were collected for analysis of the possible poisonous factor. Although suspect, none of the samples could be unambiguously related to the observed illness. Chemical, toxicological, and histopathological investigations have not so far revealed the nature of the poisonous factor, but several neurotoxic agents that are known to cause comparable leucoencephalopathies have been ruled out. This appears to be the first manifestation of the poisonous potential of the unknown causative factor.

摘要

本文描述了47例海绵状白质脑病患者，除肺部肺泡巨噬细胞有褐色色素沉着外，无其他一致的异常表现。11例患者已死亡。流行病学研究表明，该病病因是吸入了含毒海洛因蒸气（热解产物）。这些海洛因主要在荷兰阿姆斯特丹的黑市上销售。为分析可能的有毒因素，收集了170多个可疑海洛因样本。尽管这些样本可疑，但没有一个能明确与所观察到的疾病相关。到目前为止，化学、毒理学和组织病理学研究尚未揭示有毒因素的性质，但已知会导致类似白质脑病的几种神经毒性剂已被排除。这似乎是未知致病因素潜在毒性的首次表现。