Duvoisin R C, Heikkila R E, Manzino L
Neurology. 1982 Dec;32(12):1387-91. doi: 10.1212/wnl.32.12.1387.
In rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal system we compared the behavioral effects of pergolide with those of L-dopa, bromocriptine, and lergotrile. In this animal model of parkinsonism, doses of 0.25 mg per kilogram pergolide (free base) induced vigorous circling for 24 hours. Pergolide was more potent than bromocriptine or lergotrile. Pretreatment with alpha-methylparatyrosine nearly abolished the effects of bromocriptine, markedly diminished the effects of lergotrile, and only partially diminished the effects of pergolide. These findings suggest that pergolide should be more effective than bromocriptine in the treatment of parkinsonism.
在黑质纹状体系统单侧6-羟基多巴胺损伤的大鼠中，我们比较了培高利特与左旋多巴、溴隐亭和麦角腈的行为效应。在这种帕金森病动物模型中，每千克0.25毫克培高利特（游离碱）的剂量可诱导24小时的剧烈转圈行为。培高利特比溴隐亭或麦角腈更有效。用α-甲基对酪氨酸预处理几乎消除了溴隐亭的作用，显著减弱了麦角腈的作用，而仅部分减弱了培高利特的作用。这些发现表明，培高利特在治疗帕金森病方面应比溴隐亭更有效。
