Gianutsos G, Palmeri J L
Psychopharmacology (Berl). 1983;79(4):329-31. doi: 10.1007/BF00433412.
The effects of three structurally related dopamine (DA) agonists (pergolide, lergotrile, bromocriptine) on motor activity and induction of cage climbing behavior were compared in mice. Pergolide stimulated activity and induced cage climbing that persisted for at least 5 h. Lergotrile depressed activity and failed to induce climbing over a wide range of doses. Bromocriptine produced stimulation and climbing, but only after a 2-3 h delay following injection. The qualitative differences among these drugs may represent an action involving different DA receptor subjects.
比较了三种结构相关的多巴胺（DA）激动剂（培高利特、麦角腈、溴隐亭）对小鼠运动活性和笼内攀爬行为诱导的影响。培高利特刺激活性并诱导笼内攀爬，这种行为持续至少5小时。麦角腈抑制活性，在很宽的剂量范围内都不能诱导攀爬。溴隐亭产生刺激和攀爬，但仅在注射后2 - 3小时的延迟之后。这些药物之间的定性差异可能代表涉及不同DA受体亚型的作用。
