Kew M C, Hopp M, Rothberg A
S Afr Med J. 1982 Dec 4;62(24):905-6.
An 11-year-old girl who was taking two appetite-suppressant agents as part of a weight-reducing regimen developed heat-stroke while taking part in a 'nature hike' at an ambient temperature of 34 degrees C. The other 107 participating children suffered no significant ill-effects. Sympathomimetic amines used as appetite suppressants can produce heat intolerance by two mechanisms: they increase endogenous heat production as a result of their stimulatory effects on the central nervous system, and they impede the dissipation of heat from the body by producing peripheral vasoconstriction.
一名11岁女孩在减肥疗程中服用两种食欲抑制剂，在环境温度为34摄氏度时参加“自然徒步”活动时发生中暑。其他107名参与的儿童未出现明显不良影响。用作食欲抑制剂的拟交感神经胺可通过两种机制导致耐热性降低：它们对中枢神经系统的刺激作用会增加内源性产热，并且它们会通过引起外周血管收缩来阻碍身体散热。
