抗精神病药物所致中暑后的小脑综合征
Cerebellar syndrome following neuroleptic induced heat stroke.
作者信息
Lefkowitz D, Ford C S, Rich C, Biller J, McHenry L C
出版信息
J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):183-5. doi: 10.1136/jnnp.46.2.183.
Abstract
We report a patient in whom extreme hyperthermia, rhabdomyolysis, acute renal failure and a residual pancerebellar syndrome occurred while taking a combination of perphenazine and amitriptyline. We postulate that impaired thermoregulation due to psychotropic drugs was responsible for the development of heat stroke and that the cerebellar syndrome resulted directly from the elevated temperature.
摘要
我们报告了一名患者，该患者在服用奋乃静和阿米替林的组合药物时出现了极度高热、横纹肌溶解、急性肾衰竭以及残留的全小脑综合征。我们推测，精神药物导致的体温调节受损是中暑发生的原因，而小脑综合征直接由体温升高所致。
相似文献
1
Cerebellar syndrome following neuroleptic induced heat stroke.抗精神病药物所致中暑后的小脑综合征
J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):183-5. doi: 10.1136/jnnp.46.2.183.
2
Pharmacologic effects on thermoregulation: mechanisms of drug-related heatstroke.对体温调节的药理作用：药物相关性中暑的机制
J Toxicol Clin Toxicol. 1989;27(4-5):199-224. doi: 10.3109/15563658908994419.
3
Acute delirium in amitriptyline-perphenazine therapy of alcoholism.阿米替林-奋乃静治疗酒精中毒时的急性谵妄
Clin Toxicol. 1971 Mar;4(1):5-10. doi: 10.3109/15563657108990143.
4
Drug-induced heat stroke.药物性中暑
Can Med Assoc J. 1983 Apr 15;128(8):957-9.
5
[Psychiatric drugs as risk factor in fatal heat stroke].[精神科药物作为致死性中暑的危险因素]
Ned Tijdschr Geneeskd. 1995 Jul 8;139(27):1391-3.
6
Heat stroke associated with medications having anticholinergic effects.
Minn Med. 1977 Feb;60(2):103-6.
7
Neuroleptic-induced parkinsonism facilitated by alcohol.酒精促发的抗精神病药物所致帕金森综合征
J Med Soc N J. 1978 Jun;75(6):473-4.
8
Heat stroke in phenothiazine-treated patients: a report of three fatalities.吩噻嗪治疗患者的中暑：三例死亡报告。
Am J Psychiatry. 1970 Jun;126(12):1787-90. doi: 10.1176/ajp.126.12.1787.
9
A case of progressive hemichorea responsive to high-dose reserpine.一例对大剂量利血平有反应的进行性偏侧舞蹈症病例。
J Clin Psychiatry. 1986 Mar;47(3):149-50.
10
Drug-related heatstroke.药物相关性中暑
Pharmacol Ther. 1984;26(3):345-88. doi: 10.1016/0163-7258(84)90040-8.
引用本文的文献
1
Medications, epilepsy and climate change: Added layers of complexity.药物、癫痫与气候变化：复杂性的叠加层面。
Br J Clin Pharmacol. 2025 Aug;91(8):2205-2221. doi: 10.1002/bcp.70108. Epub 2025 May 27.
2
Antipsychotic Medication-Induced Hyperthermia Leading to Cerebrovascular Accident: A Case Report.抗精神病药物所致高热导致脑血管意外：一例报告
Cureus. 2021 Oct 11;13(10):e18651. doi: 10.7759/cureus.18651. eCollection 2021 Oct.
3
Cerebellar degeneration following neuroleptic malignant syndrome.抗精神病药恶性综合征后的小脑变性
Postgrad Med J. 1997 Nov;73(865):735-6. doi: 10.1136/pgmj.73.865.735.
4
Cerebellar gait ataxia following neuroleptic malignant syndrome.抗精神病药恶性综合征后的小脑性步态共济失调
J Neurol. 1996 Jan;243(1):101-2. doi: 10.1007/BF00878540.
5
Spinal cord lesions in heat stroke.中暑中的脊髓损伤。
J Neurol Neurosurg Psychiatry. 1985 Oct;48(10):1065-7. doi: 10.1136/jnnp.48.10.1065.
6
Pancerebellar syndrome in heat stroke: clinical course and CT scan findings.中暑所致全小脑综合征：临床病程及CT扫描结果
Neuroradiology. 1987;29(3):294-6. doi: 10.1007/BF00451771.
7
Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury.抗精神病药恶性综合征中的小脑变性：神经病理学发现及关于热相关神经系统损伤的文献综述
J Neurol Neurosurg Psychiatry. 1989 Mar;52(3):387-91. doi: 10.1136/jnnp.52.3.387.
本文引用的文献
1
An unusual complication following thyroidectomy: heatstroke with permanent cerebellar damage.甲状腺切除术后一种罕见的并发症：中暑伴永久性小脑损伤。
Ann Intern Med. 1950 Oct;33(4):1036-41. doi: 10.7326/0003-4819-33-4-1036.
2
Neuroleptic malignant syndrome caused by dopamine depleting drugs.由多巴胺耗竭药物引起的神经阻滞剂恶性综合征。
Neurology. 1982 Feb;32(2):218-9. doi: 10.1212/wnl.32.2.218-a.
3
Neuroleptic malignant syndrome caused by dopamine-depleting drugs in a patient with Huntington disease.亨廷顿病患者因多巴胺耗竭药物引发的神经阻滞剂恶性综合征。
Neurology. 1981 Aug;31(8):1022-5. doi: 10.1212/wnl.31.8.1022.
4
Neuroleptic malignant syndrome: a pathogenetic role for dopamine receptor blockade?抗精神病药恶性综合征：多巴胺受体阻断的发病机制作用？
Neurology. 1981 Feb;31(2):132-7. doi: 10.1212/wnl.31.2.132.
5
The neuroleptic malignant syndrome.神经阻滞剂恶性综合征
J Clin Psychiatry. 1980 Mar;41(3):79-83.
6
Persistent neurological deficits in heat stroke.中暑后持续存在的神经功能缺损。
Neurology. 1970 Apr;20(4):336-40. doi: 10.1212/wnl.20.4.336.
7
Amphetamine intoxication with coagulopathy, hyperthermia, and reversible renal failure. A syndrome resembling heatstroke.苯丙胺中毒伴凝血病、高热及可逆性肾衰竭。一种类似中暑的综合征。
Ann Intern Med. 1970 Jul;73(1):81-5. doi: 10.7326/0003-4819-73-1-81.
8
Heat stroke.中暑
Mayo Clin Proc. 1966 Jul;41(7):470-82.
9
Environmental heat illness. An eclectic review.环境性热疾病。综合述评。
Arch Intern Med. 1974 May;133(5):841-64.
10
Letter: Permanent brain damage after lithium intoxication.信件：锂中毒后永久性脑损伤。
Br Med J. 1973 Dec 15;4(5893):673. doi: 10.1136/bmj.4.5893.673-a.
Zotero 插件