文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Pass M A, Seawright A A

Comp Biochem Physiol C Comp Pharmacol. 1982;73(2):419-22. doi: 10.1016/0306-4492(82)90146-0.

The effect of the formamidine pesticide amitraz on the motility of isolated pieces of guinea-pig ileum was studied. 2. Contractions of the ileum stimulated by histamine and the histamine H1 agonists 2-methylhistamine and 2-pyridylethylamine were inhibited by amitraz at a concentration of 1 microgram/ml. 3. Amitraz did not inhibit contractions stimulated by acetylcholine, methacholine or dimethylphenylpiperazinium. 4. When pieces of intestine were left exposed to amitraz for several minutes they began to contract. These contractions appeared as rhythmic contractions and their strength did not appear to be increased by increasing the concentration of amitraz. 5. It is concluded that amitraz inhibits the action of histamine H1 agonists on the guinea-pig ileum and itself has a weak agonist effect.

研究了脒基农药双甲脒对豚鼠离体回肠段运动的影响。2. 浓度为1微克/毫升的双甲脒可抑制组胺以及组胺H1激动剂2-甲基组胺和2-吡啶乙胺刺激引起的回肠收缩。3. 双甲脒不抑制乙酰胆碱、醋甲胆碱或二甲基苯基哌嗪鎓刺激引起的收缩。4. 当肠段暴露于双甲脒几分钟后，它们开始收缩。这些收缩表现为节律性收缩，增加双甲脒浓度似乎并未增强其强度。5. 得出结论：双甲脒抑制组胺H1激动剂对豚鼠回肠的作用，且自身具有较弱的激动剂效应。

Pass M A, Seawright A A

Comp Biochem Physiol C Comp Pharmacol. 1982;73(2):419-22. doi: 10.1016/0306-4492(82)90146-0.

The effect of the formamidine pesticide amitraz on the motility of isolated pieces of guinea-pig ileum was studied. 2. Contractions of the ileum stimulated by histamine and the histamine H1 agonists 2-methylhistamine and 2-pyridylethylamine were inhibited by amitraz at a concentration of 1 microgram/ml. 3. Amitraz did not inhibit contractions stimulated by acetylcholine, methacholine or dimethylphenylpiperazinium. 4. When pieces of intestine were left exposed to amitraz for several minutes they began to contract. These contractions appeared as rhythmic contractions and their strength did not appear to be increased by increasing the concentration of amitraz. 5. It is concluded that amitraz inhibits the action of histamine H1 agonists on the guinea-pig ileum and itself has a weak agonist effect.

研究了脒基农药双甲脒对豚鼠离体回肠段运动的影响。2. 浓度为1微克/毫升的双甲脒可抑制组胺以及组胺H1激动剂2-甲基组胺和2-吡啶乙胺刺激引起的回肠收缩。3. 双甲脒不抑制乙酰胆碱、醋甲胆碱或二甲基苯基哌嗪鎓刺激引起的收缩。4. 当肠段暴露于双甲脒几分钟后，它们开始收缩。这些收缩表现为节律性收缩，增加双甲脒浓度似乎并未增强其强度。5. 得出结论：双甲脒抑制组胺H1激动剂对豚鼠回肠的作用，且自身具有较弱的激动剂效应。