Fontaine J, Famaey J P, Reuse J
Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):51-4. doi: 10.1007/BF00586596.
Low concentrations (0.63 and 1.25 ng/ml) of caerulein increase the submaximal contractions of the guinea-pig isolated ileum induced by several agonists and electrical stimulation. These effects of the polypeptide are due partly to neuronal pathways (i.e., a ganglionic stimulation) and partly to a non specific muscular sensitization. At higher concentrations of caerulein the effects of all the agonists were decreased. This seems related to the contractile effect of the peptide itself on the longitudinal muscle which interfers non specifically with the development of contractions induced by any other agonist.
低浓度（0.63和1.25纳克/毫升）的蛙皮素可增强几种激动剂和电刺激诱导的豚鼠离体回肠的次最大收缩。该多肽的这些作用部分归因于神经通路（即神经节刺激），部分归因于非特异性肌肉致敏。在较高浓度的蛙皮素作用下，所有激动剂的作用均减弱。这似乎与该肽本身对纵肌的收缩作用有关，该作用非特异性地干扰了任何其他激动剂诱导的收缩的发展。
