DiMarino A J, Cohen S
Dig Dis Sci. 1982 Dec;27(12):1063-6. doi: 10.1007/BF01391441.
The effect of the beta2-adrenergic agonist, carbuterol, was studied on the lower esophageal sphincter (LES) pressure in normals and in patients with achalasia. In normals, the mean LES pressure decreased from 23.1 +/- 6.2 mm Hg (mean +/- SEM) to 16.0 +/- 5.0 mm Hg at a 4.0-mg dose of carbuterol (P less than 0.05). In patients with achalasia, the mean LES pressure decreased from 50.1 +/- 5.1 mm Hg to 22.7 +/- 2.4 mm Hg after a 4.0-mg dose of carbuterol (P less than 0.01). The duration of action following oral administration exceeded 90 min. These studies indicate that the LES in man has beta2-adrenergic receptors that mediate a reduction in pressure. The magnitude of LES pressure reduction in patients with achalasia suggests that this drug may be of therapeutic benefit.
研究了β2-肾上腺素能激动剂卡布特罗对正常人和贲门失弛缓症患者下食管括约肌（LES）压力的影响。在正常人中，服用4.0毫克卡布特罗后，LES平均压力从23.1±6.2毫米汞柱（平均值±标准误）降至16.0±5.0毫米汞柱（P<0.05）。在贲门失弛缓症患者中，服用4.0毫克卡布特罗后，LES平均压力从50.1±5.1毫米汞柱降至22.7±2.4毫米汞柱（P<0.01）。口服后的作用持续时间超过90分钟。这些研究表明，人类的LES具有介导压力降低的β2-肾上腺素能受体。贲门失弛缓症患者LES压力降低的幅度表明，这种药物可能具有治疗益处。
