哮喘患者的胃肠道症状
Gastrointestinal symptoms in patients with asthma.
作者信息
Caffarelli C, Deriu F M, Terzi V, Perrone F, De Angelis G, Atherton D J
机构信息
Clinica Pediatrica, Universitá di Parma, Via Gramsci 14, 43100 Parma, Italy.
出版信息
Arch Dis Child. 2000 Feb;82(2):131-5. doi: 10.1136/adc.82.2.131.
AIMS
Minor gastrointestinal abnormalities have been reported in children with asthma, but the prevalence of gastrointestinal symptoms in these children has not been studied.
METHODS
75 children with bronchial asthma and an age and sex matched control group were recruited. Parents completed a questionnaire on gastrointestinal symptoms and on asthma. Weight and height were measured; a clinical evaluation of asthma was undertaken and skin prick tests were performed.
RESULTS
Children with asthma had a significantly greater frequency of gastrointestinal symptoms, particularly diarrhoea, vomiting, and abdominal pain, than did controls. Gastrointestinal symptoms were slightly more common in children with atopic symptoms other than asthma, or with positive skin prick tests to foods. There was no association between current gastrointestinal symptoms and medications or attacks of asthma.
CONCLUSIONS
The occurrence of gastrointestinal symptoms appears to be common in children with asthma. These symptoms might be caused by an atopic gastroenteropathy, which might play a part in the pathogenesis of asthma in some cases.
目的
已有报道称哮喘儿童存在轻微胃肠道异常，但这些儿童胃肠道症状的患病率尚未得到研究。
方法
招募了75名支气管哮喘儿童以及一个年龄和性别匹配的对照组。家长们完成了一份关于胃肠道症状和哮喘的问卷。测量了体重和身高；对哮喘进行了临床评估并进行了皮肤点刺试验。
结果
哮喘儿童胃肠道症状的发生率明显高于对照组，尤其是腹泻、呕吐和腹痛。胃肠道症状在除哮喘外有特应性症状或食物皮肤点刺试验呈阳性的儿童中略为常见。目前的胃肠道症状与药物或哮喘发作之间没有关联。
结论
胃肠道症状在哮喘儿童中似乎很常见。这些症状可能由特应性胃肠病引起，在某些情况下可能在哮喘的发病机制中起作用。
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