对β-肾上腺素能受体刺激的反应性：年龄的影响具有心脏选择性。
Responsiveness to beta-adrenergic receptor stimulation: the effects of age are cardioselective.
作者信息
Kendall M J, Woods K L, Wilkins M R, Worthington D J
出版信息
Br J Clin Pharmacol. 1982 Dec;14(6):821-6. doi: 10.1111/j.1365-2125.1982.tb02043.x.
Abstract
1 To examine the influence of age on beta-adrenergic receptor mechanisms, we have observed the cardiovascular, bronchial and metabolic effects of an intravenous infusion of the beta-adrenoceptor agonist terbutaline in healthy young and elderly female subjects (mean ages 20.9 and 72.1 years respectively). 2 There was a highly significant fall in systolic blood pressure in the elderly, in contrast to the rise in systolic pressure seen in the young subjects. A similar fall in diastolic pressure occurred in both groups, indicating comparable beta-adrenoceptor-mediated vasodilatation. The fall in mean arterial pressure was significantly greater in the old than in the young subjects. The increase in heart rate was significantly less in the elderly. 3 Changes in plasma glucose and potassium during the infusion were similar in the two groups. 4 The observed abnormality of myocardial sensitivity to beta-adrenergic receptor stimulation, which is not associated with a generalized blunting of beta-adrenoceptor mediated effects, may significantly impair autonomic cardiovascular regulation in the elderly.
摘要
- 为研究年龄对β-肾上腺素能受体机制的影响，我们观察了静脉输注β-肾上腺素能受体激动剂特布他林对健康年轻和老年女性受试者（平均年龄分别为20.9岁和72.1岁）心血管、支气管和代谢方面的影响。2. 老年受试者收缩压显著下降，而年轻受试者收缩压升高。两组舒张压均出现类似下降，表明β-肾上腺素能受体介导的血管舒张作用相当。老年受试者平均动脉压下降幅度明显大于年轻受试者。老年人心率增加幅度明显较小。3. 输注过程中两组血浆葡萄糖和钾的变化相似。4. 观察到的心肌对β-肾上腺素能受体刺激敏感性异常，并非与β-肾上腺素能受体介导效应的普遍减弱相关，可能会显著损害老年人自主心血管调节功能。
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