Dillon N, Chung S, Kelly J, O'Malley K
Clin Pharmacol Ther. 1980 Jun;27(6):769-72. doi: 10.1038/clpt.1980.108.
Beta adrenoceptor-mediated responsiveness to isoproterenol was compared in young and old subjects using the production of cyclic adenosine monophosphate (cyclic AMP) by lymphocytes as an index. The mean log dose-response curve for the elderly group was displaced to the right and the mean maximum response was less than that for the young subjects. The results corroborate evidence of a decreased response to isoproterenol-induced increases in heart rate in the elderly and raise the possibility of a generalized decrease in beta adrenoceptor-mediated functions in old age.
以淋巴细胞产生环磷酸腺苷（cAMP）作为指标，比较了年轻和老年受试者中β肾上腺素能受体介导的对异丙肾上腺素的反应性。老年组的平均对数剂量反应曲线向右移位，平均最大反应低于年轻受试者。这些结果证实了老年人对异丙肾上腺素诱导的心率增加反应降低的证据，并增加了老年期β肾上腺素能受体介导功能普遍下降的可能性。
