β-肾上腺素能受体拮抗剂对高血压患者周围血管症状患病率的影响。
Effect of beta-adrenoceptor antagonists on prevalence of peripheral vascular symptoms in hypertensive patients.
作者信息
Steiner J A, Cooper R, McPherson K, Riley A J
出版信息
Br J Clin Pharmacol. 1982 Dec;14(6):833-7. doi: 10.1111/j.1365-2125.1982.tb02045.x.
1 Eight hundred patients were approached by questionnaire to give details of side effects of their antihypertensive medications. The response rate was 72.8%. The percentage of those questioned who were taking beta-adrenoceptor antagonists at the time was 54.6%. 2 Raynaud's phenomenon (P less than 0.05) and complaints of cold extremities (P less than 0.001) were significantly more frequent in women than in men, 74.8% of women complained of cold extremities. 3 Exposure to beta-adrenoceptor antagonists did not increase the prevalence of Raynaud's phenomenon in either men or women in the study, but did increase the prevalence of cold extremities in men (P less than 0.001). Propranolol, labetalol, oxprenolol and possibly atenolol were likely to produce such side effects. Smoking and the addition of vasodilators did not alter the effect of beta-adrenoceptor blockers on peripheral vascular symptoms. Complaints of cold extremities were not associated with an excess of complaints of other side effects.
- 通过问卷调查的方式对800名患者进行了询问，以了解他们服用的抗高血压药物的副作用详情。回复率为72.8%。当时正在服用β-肾上腺素能受体拮抗剂的被调查者的比例为54.6%。2. 雷诺现象（P<0.05）和四肢发冷的主诉（P<0.001）在女性中比在男性中明显更常见，74.8%的女性主诉四肢发冷。3. 在该研究中，接触β-肾上腺素能受体拮抗剂在男性和女性中均未增加雷诺现象的患病率，但确实增加了男性四肢发冷的患病率（P<0.001）。普萘洛尔、拉贝洛尔、氧烯洛尔以及可能的阿替洛尔都可能产生此类副作用。吸烟和添加血管扩张剂并未改变β-肾上腺素能受体阻滞剂对外周血管症状的影响。四肢发冷的主诉与其他副作用主诉的增加无关。
Zotero 插件