雷诺现象作为β受体阻滞剂治疗高血压时的副作用。
Raynaud's phenomenon as side effect of beta-blockers in hypertension.
作者信息
Marshall A J, Roberts C J, Barritt D W
出版信息
Br Med J. 1976 Jun 19;1(6024):1498-9. doi: 10.1136/bmj.1.6024.1498.
Abstract
A series of 102 hypertensive patients were assessed for the frequency of symptoms of Raynaud's phenomenon and absent peripheral pulses. Out of 21 patients receiving methyldopa alone only one had cold hands and feet whereas among patients on beta-blockers the incidence was 50%. The frequency of both symptoms and absent pulses was highest in patients taking propranolol compared with those taking atenolol or oxprenolol. Patients without a foot pulse were much more likely to have cold hands. A change from propranolol to oxprenolol in some symptomatic patients resulted in improvement. In two patients the skin temperature fell after an 80-mg dose of propranolol. The mechanism by which beta-blockers induce Raynaud's phenomenon is still not clear.
摘要
对102例高血压患者进行了雷诺现象症状发生频率及外周脉搏缺失情况的评估。在仅接受甲基多巴治疗的21例患者中，只有1例有手脚冰凉的症状，而在接受β受体阻滞剂治疗的患者中，这一症状的发生率为50%。与服用阿替洛尔或氧烯洛尔的患者相比，服用普萘洛尔的患者出现这两种症状及脉搏缺失的频率最高。没有足脉搏的患者更易出现双手冰凉。一些有症状的患者从普萘洛尔换成氧烯洛尔后症状有所改善。2例患者服用80毫克普萘洛尔后皮肤温度下降。β受体阻滞剂诱发雷诺现象的机制仍不清楚。
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本文引用的文献
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