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[主要影响外周M-胆碱反应系统的化合物对骨髓嗜酸性粒细胞的作用]

[Action of compounds which predominantly affect the peripheral M-cholinoreactive systems on the bone marrow eosinophils].

作者信息

Deshevoĭ Iu B, Gorizontov P D

出版信息

Biull Eksp Biol Med. 1982 Nov;94(11):61-3.

PMID:6129908
Abstract

Experiments on rats have shown that the blockade of M-cholinoreceptors with atropine (50,100 and 150 mg/kg) delays, while the stimulation of the M-cholinoreceptors with aceclidine (5, 10 and 15 mg/kg) intensifies the release of mature eosinophils from the bone marrow to the circulating blood. It is concluded that the peripheral M-cholinoreactive systems participate in the control of the release of the mature bone marrow eosinophils into the blood.

摘要

对大鼠的实验表明,用阿托品(50、100和150毫克/千克)阻断M胆碱受体可延迟成熟嗜酸性粒细胞从骨髓释放到循环血液中,而用醋甲胆碱(5、10和15毫克/千克)刺激M胆碱受体则会增强这种释放。得出的结论是,外周M胆碱反应系统参与控制成熟骨髓嗜酸性粒细胞释放到血液中的过程。

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